Hedgehog signaling and maintenance of homeostasis in the intestinal epithelium.
نویسندگان
چکیده
Homeostasis of the rapidly renewing intestinal epithelium depends on a balance between cell proliferation and loss. Indian hedgehog (Ihh) acts as a negative feedback signal in this dynamic equilibrium. We discuss recent evidence that Ihh may be one of the key epithelial signals that indicates epithelial integrity to the underlying mesenchyme.
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عنوان ژورنال:
- Physiology
دوره 27 3 شماره
صفحات -
تاریخ انتشار 2012